Ca Release Unit Heterogeneity and Entrainment of Ca Waves in Cardiac Myocytes
نویسندگان
چکیده
منابع مشابه
Luminal Ca Controls Termination and Refractory Behavior of Ca -Induced Ca Release in Cardiac Myocytes
Despite extensive research, the mechanisms responsible for the graded nature and early termination of Ca -induced Ca release (CICR) from the sarcoplasmic reticulum (SR) in cardiac muscle remain poorly understood. Suggested mechanisms include cytosolic Ca -dependent inactivation/adaptation and luminal Ca -dependent deactivtion of the SR Ca release channels/ryanodine receptors (RyRs). To explore ...
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Examining calcium spark morphology and its relationship to the structure of the cardiac myocyte offers a direct means of understanding excitation-contraction coupling mechanisms. Traditional confocal line-scanning achieves excellent temporal spark resolution but at the cost of spatial information in the perpendicular dimension. To address this, we developed a methodology to identify and analyze...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2013
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.11.2419